sparsentan will lower the extent or influence of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Check. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and cuts down efficacy linked to these substrates.itraconazole will raise the level or influence of modafinil by impacting hepatic/intestinal enzyme CYP… Read More